Yam Koj Yuav Tsum Paub Txog Kev Pw tsaug zog thiab Alzheimer's

Kuv ua haujlwm txhua hnub ntawm kev ua kom kuv lub paj hlwb zoo. Kuv nyeem, Kuv ua si ua si nrog kuv cov menyuam (Cov lus nrog phooj ywg, leej twg?), Noj tshuaj ntxiv, koj lub npe. Kuv noj cov zaub mov uas hais txog zaub mov hauv lub hlwb - suav nrog cov omega 3s uas kuv tau sau txog tsis ntev los no. Kuv kuj nco ntsoov kom pw ntau.

Kuv tabtom ua haujlwm niaj hnub no kom kuv lub peev xwm kev txawj ntse nyob tau ntau caum xyoo hauv txoj kev.

Tab sis kev ua neej nyob noj qab haus huv tsis ua rau peb tsis muaj kev txhawj xeeb txog kev pheej hmoo mus sij hawm ntev rau kev txawj ntse poob qis thiab kab mob neurodegenerative zoo li dementia. Coob leej ntawm kuv cov neeg mob uas tau dhau mus txog hnub nyoog nruab nrab tham nrog kuv txog lawv qhov kev ntshai poob kev nco, kev xav meej meej, thiab kev paub kev paub nrog lub hnub nyoog - thiab lawv txhawj xeeb txog Alzheimer's tshwj xeeb.

Muaj kev tshawb fawb tshiab txog kev sib txuas ntawm kev pw tsaug zog thiab Alzheimer's Kuv xav qhia rau koj - kev tshawb fawb uas ua rau peb nkag siab tob txog kev pw tsaug zog tsis zoo thiab Alzheimer's tus kab mob li cas. Feem ntau ntawm peb tej zaum paub, lossis paub txog, ib tus neeg uas tau cuam tshuam los ntawm Alzheimer's. Hmoov tsis zoo, cov lej ua qhov ntawd. Raws li Alzheimer's Association, ib tus neeg hauv Asmeskas txhim kho Alzheimer's disease txhua 65 feeb. Niaj hnub no, muaj 5.7 lab tus neeg Asmeskas nyob nrog tus kab mob neurodegenerative no - feem ntau yog hom dementia. Txog xyoo 2050, kwv yees kwv yees tias tus lej yuav nce mus rau 14 lab.

Dab tsi ua rau Alzheimer's disease?

Cov lus teb nyuaj yog, peb tseem tsis tau paub. Cov kws tshawb fawb tau ua haujlwm hnyav txhawm rau txheeb xyuas Alzheimer's keeb kwm. Txawm hais tias peb tseem tsis tau paub yog vim li cas, yam peb paub yog tus kab mob ua rau muaj teeb meem hauv txoj kev ua haujlwm ntawm lub hlwb.

Ntau lab tus neurons hauv peb lub paj hlwb tau ua haujlwm tas li, ua rau peb muaj sia nyob thiab ua haujlwm zoo. Lawv ua rau peb xav thiab txiav txim siab, khaws thiab khaws nco thiab kawm, paub lub ntiaj teb ib puag ncig peb los ntawm peb qhov kev nkag siab, hnov ​​peb txhua yam kev xav, thiab qhia peb tus kheej hauv hom lus thiab tus cwj pwm.

Cov kws tshawb fawb xav tias muaj ntau hom protein tso rau hauv uas ua rau lub hlwb puas tsuaj, ua rau muaj teeb meem loj zuj zus nrog kev nco, kev kawm, kev xav, thiab tus cwj pwm - cov cim tseem ceeb ntawm Alzheimer's. Ob ntawm cov protein no yog:

• Beta-amyloid cov protein, uas tsim los tsim cov plaques ncig lub hlwb hlwb.
• Tau cov protein, uas tsim mus rau hauv cov pob zeb zoo li cov pob txha-hu ua tangles-hauv hlwb hlwb.

Cov kws tshawb fawb tseem tab tom ua haujlwm txhawm rau nkag siab tias cov quav hniav thiab tangles pab txhawb rau Alzheimer's disease thiab nws cov tsos mob li cas. Nrog hnub nyoog, nws yog ib txwm rau tib neeg los txhim kho qee qhov kev tsim no hauv lub hlwb. Tab sis cov tib neeg nrog Alzheimer's tsim cov quav hniav thiab tangles hauv qhov ntau dua - tshwj xeeb tshaj yog nyob rau thaj tsam ntawm lub paj hlwb ntsig txog kev nco thiab lwm yam kev ua haujlwm nyuaj.

Muaj kev loj hlob ntawm lub cev ntawm kev tshawb fawb uas qhia txog kev pw tsis zoo thiab tsis tsaug zog txaus tau txuas rau ntau dua beta-amyloid thiab tau cov protein hauv lub hlwb. Ib txoj kev tshawb fawb tso tawm xyoo 2017 pom tias hauv cov neeg muaj hnub nyoog noj qab haus huv, cuam tshuam rau kev pw tsaug zog qeeb tau cuam tshuam nrog nce qib beta-amyloid cov protein.

Kev tsaug zog thaum nruab hnub tau txuas nrog Alzheimer's ntsig txog cov protein tso rau hauv lub hlwb

Ib txoj kev tshawb fawb nyuam qhuav tso tawm qhia tias kev tsaug zog thaum nruab hnub ntau dhau yog txuas nrog ntau dua beta-amyloid protein hauv lub hlwb tso rau hauv cov neeg laus dua noj qab haus huv. Cov kws tshawb fawb ntawm Mayo Clinic tau teeb tsa hauv lawv txoj kev tshawb fawb los teb cov lus nug loj txog qhov ua rau muaj mob: puas yog kev tsim cov beta-amyloid protein ua rau pw tsis zoo, lossis puas cuam tshuam kev pw tsaug zog ua rau cov protein ntau ntau?

Lub Tsev Kho Mob Mayo twb tau ua tiav txoj kev tshawb fawb ntev txog kev hloov pauv kev paub uas cuam tshuam nrog kev laus. Los ntawm qhov kev kawm uas twb tau ua tiav lawm, cov kws tshawb fawb tau xaiv 283 tus neeg, uas muaj hnub nyoog tshaj 70 xyoo thiab tsis muaj dementia, los tshuaj xyuas qhov kev sib raug zoo ntawm lawv cov qauv kev pw tsaug zog thiab lawv cov beta-amyloid cov protein ua haujlwm.

Thaum pib ntawm txoj kev tshawb fawb, ze li ib-peb lub hlis-me ntsis ntau dua 22 feem pua-ntawm cov neeg laus hauv pab pawg tau tshaj tawm tias lawv tau pw tsaug zog thaum nruab hnub ntau dhau.Kev tsaug zog ntau dhau thaum nruab hnub yog qhov tseeb, qhov taw qhia tseem ceeb uas koj tsis tau pw txaus thaum hmo ntuj - thiab nws yog cov tsos mob cuam tshuam nrog kev pw tsaug zog ib txwm muaj, suav nrog pw tsis tsaug zog.

Tshaj li xya-xyoo lub sijhawm, cov kws tshawb fawb tau saib cov neeg mob 'beta-amyloid kev ua haujlwm siv PET scans. Lawv pom:

Cov tib neeg nrog pw tsaug zog nruab hnub ntau dhau thaum pib ntawm txoj kev tshawb fawb feem ntau yuav muaj qib beta-amyloid ntau dua nyob rau lub sijhawm.

Hauv cov neeg pw tsaug zog tsis txaus, qhov tseem ceeb ntawm beta-amyloid tsim tsa tau tshwm sim hauv ob qhov tshwj xeeb ntawm lub hlwb: lub hauv ntej cingulate thiab cingulate precuneus. Hauv cov tib neeg nrog Alzheimer's, ob thaj chaw ntawm lub hlwb zoo li qhia qib siab ntawm beta-amyloid tsim.

Txoj kev tshawb no tsis muab cov lus teb meej rau lo lus nug seb nws puas pw tsaug zog uas ua rau muaj cov protein amyloid tsim, lossis amyloid tso nyiaj uas ua rau muaj teeb meem pw tsaug zog - lossis qee qhov ntawm ob qho tib si. Tab sis nws qhia tias kev tsaug zog ntau dhau thaum nruab hnub tuaj yeem yog ib qho cim qhia ntxov txog Alzheimer's disease.

Mayo Clinic txoj kev tshawb fawb txuas nrog cov kev tshawb fawb tsis ntev los no uas tau saib ntawm kev sib raug zoo ntawm kev pw tsis zoo thiab Alzheimer txoj kev pheej hmoo. Cov kws tshawb fawb ntawm University of Wisconsin, Madison tau tshawb nrhiav qhov ua tau zoo ntawm kev pw tsaug zog zoo thiab ntau yam cim tseem ceeb rau Alzheimer's, pom hauv cov leeg txha caj qaum, suav nrog cov cim rau beta-amyloid cov protein thiab cov protein tau uas ua rau cov hlab ntsha-cell strangling tangles.

Hauv txoj kev tshawb fawb no, cov kws tshawb fawb tau sim tib neeg yam tsis muaj Alzheimer's lossis dementia - tab sis lawv tau xaiv tshwj xeeb rau cov tib neeg uas muaj kev pheej hmoo siab rau tus kab mob, txawm yog vim lawv muaj niam txiv nrog Alzheimer's lossis vim lawv nqa cov noob tshwj xeeb (apolipoprotein E gene), uas yog txuas nrog tus kab mob.

Zoo li lawv cov phooj ywg ntawm Mayo, Madison cov kws tshawb fawb pom tias cov tib neeg uas muaj kev tsaug zog ntau dhau thaum nruab hnub pom ntau lub cim rau beta-amyloid protein. Lawv kuj pom nruab hnub pw tsaug zog txuas rau cov cim ntau ntxiv rau tau cov protein. Thiab cov tib neeg uas qhia txog kev pw tsis zoo thiab uas muaj cov lej ntau dua ntawm cov teeb meem pw tsaug zog pom ntau dua ntawm Alzheimer's biomarkers ntau dua li lawv lub suab pw tsaug zog.

Lub paj hlwb ntxuav nws tus kheej ntawm Alzheimer's ntsig txog cov protein thaum pw tsaug zog

Nws tsuas yog ob peb xyoos dhau los uas cov kws tshawb fawb tau tshawb pom yav dhau los uas tsis tau pom dua lub hauv paus hauv lub hlwb uas tshem cov pov tseg, suav nrog cov protein-amyloid cov protein cuam tshuam nrog Alzheimer's. (University of Rochester Medical Center cov kws tshawb fawb uas ua qhov kev tshawb pom no lub npe hu ua "glymphatic system," vim tias nws ua haujlwm zoo ib yam li lub cev lymphatic system hauv kev tshem cov pov tseg los ntawm lub cev, thiab ua haujlwm los ntawm lub hlwb lub hlwb glial.) Cov kws tshawb fawb tsis tau ' t tsuas yog txheeb xyuas qhov glymphatic system - qhov kev tshawb pom pib hauv thiab ntawm nws tus kheej. Lawv kuj pom tias qhov kev sib tw glymphatic nkag mus ntau dhau thaum pw tsaug zog.

Thaum peb tsaug zog, cov kws tshawb fawb tau tshawb pom, glymphatic system ua haujlwm ntau dua 10 zaug hauv kev tshem cov khib nyiab los ntawm lub hlwb.

Nov yog qee qhov kev tshawb fawb tseem ceeb tshaj plaws los qhia txog qhov tseem ceeb ntawm kev pw tsaug zog zoo rau kev noj qab haus huv lub hlwb mus sij hawm ntev. Thaum koj tsaug zog, cov kws tshawb fawb tam sim no xav tias, koj qhov kev sib tw glymphatic nce nws cov dej num kom tshem tawm cov khib nyiab uas tuaj yeem tsim kev puas tsuaj uas tau sau dhau koj hnub sawv los. Yog tias koj pw tsis zoo lossis mus pw tsis txaus tas li, koj yuav pheej hmoo ploj ntawm qhov cuam tshuam tag nrho ntawm cov txheej txheem kev ntxuav no.

Kev pw tsaug zog tsis zoo tas li txuas nrog Alzheimer's

Lwm qhov ua tau pw tsaug zog ntsig txog kev ceeb toom ntxov ntawm Alzheimer's? Teeb meem kev pw tsaug zog, raws li kev tshawb fawb tshiab. Cov kws tshawb fawb ntawm Washington University Tsev Kawm Ntawv Tshuaj Kho Mob tau taug qab cov suab paj nruag circadian thiab pw tsaug zog tsaug zog ntawm ze li 200 tus neeg laus (hnub nyoog nruab nrab, 66), thiab sim lawv txhua qhov rau thaum ntxov, ua ntej kuaj mob ntawm Alzheimer's.

Hauv 50 tus neeg mob uas tau pom ua ntej pom ntawm Alzheimer's, txhua tus ntawm lawv tau cuam tshuam kev pw tsaug zog-sawv mus. Qhov ntawd txhais tau tias lawv lub cev tsis ua raws li tus qauv uas ntseeg tau ntawm kev pw hmo ntuj thiab kev ua haujlwm nruab hnub. Lawv tau pw tsawg dua thaum hmo ntuj, thiab xav kom pw ntau dua thaum nruab hnub.

Ib qho tseem ceeb kom nco ntsoov ntawm no: Cov neeg hauv txoj kev tshawb fawb uas cuam tshuam txog kev pw tsaug zog-sawv mus tsis tau tag nrho cov neeg pw tsaug zog. Lawv tau pw txaus-tab sis lawv tau pw tsaug zog ntau dua li cov qauv hauv 24 teev ib hnub.

Txoj kev tshawb fawb no qhia tias cuam tshuam cov suab paj nruag circadian cuam tshuam tuaj yeem yog lub cim biomarker thaum ntxov rau Alzheimer's, txawm tias tsis muaj kev pw tsaug zog.

Thaum kuv cov neeg mob qhia rau kuv nrog lawv txhawj xeeb txog lawv kev noj qab nyob zoo mus sij hawm ntev thiab lawv ntshai Alzheimer's, Kuv nkag siab. Kuv yuav qhia koj qhov kuv qhia rau lawv: qhov zoo tshaj plaws uas koj tuaj yeem ua tau yog txhais koj qhov kev txhawj xeeb rau hauv kev tiv thaiv thiab saib xyuas koj tus kheej niaj hnub no, nrog lub hom phiaj txo qis koj qhov kev pheej hmoo rau kev paub tsis meej thiab kev nco qab hauv siab. Saib txhua yam uas peb paub, nws yog qhov tseeb tias tau txais kev tsaug zog zoo, pw tsaug zog zoo yog ib feem tseem ceeb ntawm txoj phiaj xwm ntawd.

Npau suav zoo,
Michael J. Breus, PhD, DABSM
Tus kws kho mob pw tsaug zog ™
www.thesleepdoctor.com